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KMID : 1134820090380060667
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 6 p.667 ~ p.673
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Antihyperlipidemic and Glycemic Control Effects of Mycelia of Inonotus obliquus Including Protein-bound Polysaccharides Extract in C57BL/6J Mice
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Kim Min-A
Jeong Yong-Seob
Chun Gie-Taek
Cha Youn-Soo
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Abstract
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The antihyperlipidemic and glycemic control effects of mycelia of Inonotus obliquus including protein-bound polysaccharides extract were investigated. In high fat diet-induced obese C57BL/6J mice, the mycelia of Inonotus obliquus including protein-bound polysaccharides extract showed significant decrease in epididymal fat tissue weight, blood triglyceride and VLDL level, triglyceride and total cholesterol level in liver, serum insulin and HOMA-IR level and AUC. Oral glucose tolerance test glucose level reduction were 4.9% (M150L; β-glucan 1.303 ㎎/㎏ bw), 9.5% (M150; β-glucan 2.606 ㎎/㎏ bw) after 180 min of glucose loading compared to H-C group. Besides, the mycelia of Inonotus obliquus including protein-bound polysaccharides extract treatment significantly increased glycogen contents in liver and adiponectin level in high fat diet-induced obese mice. In conclusion, the results showed that the mycelia of Inonotus obliquus including protein-bound polysaccharides extract possesses significant antihyperlipidemic and glycemic control effects in C57BL/6J mice.
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KEYWORD
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Inonotus obliquus, mycelia, protein bound polysaccharides, anti-hyperlipidemic effect, glycemic control
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